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Sensors with 60 nm gap junctions coated with aptamers that bind with S1 and S2 spiking proteins of the SARS-CoV-2 virus were developed. Sensor impedance changes with virus enabling rapid (~1 min), point-of-care detection. Exosomes and other nanoparticles in the saliva produce false positive signals but do not bind with aptamers and are easily removed to achieve 6% false positivity rates. A positive sensor voltage is used to attract the negatively charged SARS-CoV-2 virus to the junction and reduce sensor false negativity rates to below 7%. The limit of detection of the sensor is ~1000 viruses and can be altered by changing sensor’s lateral dimension and its transduction noise level.more » « less
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Tabib-Azar, Massood; Chowdhury, Mohammad Ashif (, IEEE Sensors Journal)
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Tabib-Azar, Massood; Brown, Braden Aaron (, IEEE Sensors Journal)
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Sinha, Kushagra; Tabib-Azar, Massood (, IEEE Sensors Journal)
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